This is the first time Atlético de Madrid are hosting Internazionale in all competitions. They’ve won seven of their last nine home games against Italian sides, drawing with Juventus is September 2019 (2-2), and losing to Milan in November 2021 (0-1).

Internazionale are winless in their last 10 away games against Spanish sides in the UEFA Champions League (D3 L7), since beating Valencia 5-1 in October 2004.

Atlético de Madrid’s 1-0 defeat in the first leg was the sixth time they’ve lost the opening leg of a UEFA Champions League knockout stage tie. They ended up progressing from the first two (v Bayer Leverkusen in 2014-15 and Barcelona in 2015-16), but have been eliminated from each of the last three (Real Madrid 2016-17, Chelsea 2020-21, Man City 2021-22).

Inter have progressed from seven of their eight previous UEFA Champions League knockout stage ties in which they won the first leg. The exception was in the 2005-06 quarter-final against Villarreal (2-1 home, 0-1 away, eliminated on away goals).

Since beating Liverpool 3-2 in March 2020, Atlético de Madrid have scored just three goals in their eight UEFA Champions League knockout stage matches. They’ve failed to score on five occasions in that run, including each of their last three (twice v Manchester City last year and in the first leg v Internazionale).

Internazionale are looking to reach the UEFA Champions League quarter-final in consecutive seasons for the third time, previously doing so in 2004-05/2005-06 and 2009-10/2010-11.

Inter are unbeaten in all seven of their UEFA Champions League matches this season, after losing last season’s final to Manchester City (W4 D3). They last had a longer run without defeat in the competition between December 2003 and March 2005 (9).

Atlético de Madrid didn’t register a single shot on target against Inter in the first leg – the only instance on record (since 2003-04) of a team failing to have a shot on target across both legs of a UEFA Champions League knockout stage tie is Deportivo de La Coruña, in their 2003-04 semi-final against FC Porto.

This will be Atlético de Madrid manager Diego Simeone’s 50th home game in charge in the UEFA Champions League, the seventh manager to reach that particular milestone. He’s lost just five of his 49 at home so far (W31 D13), with no manager losing fewer in their first 50 (Pep Guardiola and José Mourinho also 5).

Atlético de Madrid midfielder Rodrigo De Paul has created six chances following a line-breaking pass in the UEFA Champions League this season, including one in the reverse fixture against Internazionale. As of the end of the first leg matches in the round of 16, his total of six was the joint-most of any player in the competition this term (level with Jude Bellingham).