Nuno Espirito Santo names an unchanged West Ham side for the fourth game in succession.
Callum Wilson has to settle for a place on the bench after scoring the winner against Everton last weekend, while Konstantinos Mavropanos makes his 100th appearance for the Hammers.
West Ham XI: Hermansen, Walker-Peters, Mavropanos, Disasi, Diouf, Bowen, Soucek, Mateus Fernandes, Summerville, Pablo, Castellanos
You can also listen to today's 5 Live Premier League commentaries on most smart speakers. Just say "ask BBC Sounds to play Brentford v West Ham" or "ask BBC Sounds to play Arsenal v Fulham", for instance.
Sutton's predictions: Brentford v West Hampublished at 08:02 BST 2 May
08:02 BST 2 May
What a superb and much-needed win for West Ham last week against their old boss David Moyes.
The Hammers have been building momentum since the turn of the year but that result was down to a mixture of good football and good fortune - Matheus Fernandes nearly caught the ball in his own box but Everton somehow did not get given a penalty.
Brentford were unlucky not to get something at Old Trafford on Monday but they are still right in the mix for the European places, although Igor Thiago needs to find his shooting boots again after a disappointing night against Manchester United.
Brentford v West Ham: Key stats and talking pointspublished at 19:28 BST 1 May
19:28 BST 1 May
Matt Jones BBC Sport journalist
Brentford need to find some impetus late in the season to reignite their European hopes. Desperate to secure Premier League survival, West Ham United are their opponents at the Gtech Community Stadium on Saturday (15:00 BST).
Final home games crucial for Brentford
Defeat to Manchester United on Monday ended Brentford's run of five consecutive draws in the top flight. It's a sequence that has allowed Brighton and AFC Bournemouth to leap ahead of the Bees in the table. Still, Keith Andrews' side go into the weekend fixtures just two points off sixth place.
At the other end of the table, West Ham are keeping their heads above water. They left it late against Everton last time out, though, with Callum Wilson's injury-time winner ensuring Tottenham Hotspur remained in the relegation zone with just four games to play. The gap between the two London rivals is just two points.
A season that promised so much is in danger of ending with a whimper for Brentford, with hopes of European qualification now out of their hands.
The reasons for their poor form are not entirely clear. At times, they have struggled to score goals - most recently in 0-0 draws with Leeds and Fulham - while in other games they have conceded goals, as seen in the 2-1 loss at Manchester United on Monday.
If Brentford are going to get back on track, their final two home games - against West Ham and Crystal Palace - look crucial. Their other two fixtures are away at Manchester City and Liverpool.
Andrews would also be grateful if more players could contribute goals in attack. Aside from Igor Thiago. Kevin Schade has not registered a goal or an assist in his last seven games in all competitions, while Dango Ouattara has gone 10 games without scoring.
Needless to say, Brentford have been heavily reliant on the goalscoring exploits of their Brazilian striker this season. Thiago's 21 goals account for 43% of the team's total league goals — the highest proportion in the Premier League.
Bowen brilliance keeping West Ham afloat
West Ham should be confident given their recent form – they have taken 22 points from their last 13 games – but their record against Brentford leaves a lot to be desired.
They have conceded in all nine of the Premier League games between the two sides since the Bees returned to the top flight. Seven of those nine matches have been defeats for the Hammers too, which is their highest loss rate against any side they've faced five or more times in the competition.
With Brentford in a bit of a rut, this weekend could be a perfect moment for that to change. In Jarrod Bowen, West Ham arguably have one of the in-form forwards in the Premier League.
Bowen set up two more goals against Everton last weekend to take his assist tally to 10 for the season in the top flight. Coupled with his eight goals, only Harry Kane and Mason Greenwood have more goal contributions across European football's top five leagues among English players.
Nuno on 'confident' Hammers, 'tough' Brentford and Virani returnpublished at 14:17 BST 30 April
14:17 BST 30 April
George Booth BBC Sport journalist
West Ham boss Nuno Espirito Santo has been speaking to the media before Saturday's Premier League game against Brentford at the Gtech Community Stadium (kick-off 15:00 BST).
Here are the key lines from his news conference:
Nuno Espirito Santo confirmed that all of West Ham's players seemed "OK" to face Brentford despite some "small knocks" in training.
The Portuguese head coach said his manager of the month nomination was a "club nomination" as the Hammers have picked up seven points in the Premier League from three games in April. "I think the results have helped the atmosphere a lot. No matter what, we have to stick together, we have been through tough moments. We have been able to slowly change," added Nuno.
On Brentford: "All of the games in the Premier League are intense. No matter what you are fighting for. It is going to be tough and we are preparing ourselves for Brentford."
Nuno said the Hammers are "confident" in restricting the Bees' set-piece goal threat but expects Keith Andrews' side to "cause a lot of problems". "I think we can take examples of the way Brentford do things - they're very intense and very physical," added Nuno.
On Callum Wilson: "It is very difficult and sometimes very unfair that we cannot put every player to start the game. Callum is one of the players that should deserve more [minutes]. He is giving back 1,000 times more. He has been getting goals which have been points for us, which is so crucial."
On watching Tottenham's Sunday fixture against Aston Villa (19:00 BST kick-off): "Everyone is free to do whatever they want. Me, for sure, I am going to watch the game. Some players will watch the game. The priority is what you do."
On the Hammers appointing Karim Virani as the club's interim chief executive officer: "I was with him today, the message between us was clear. Let's do everything we can to help the team and accomplish our main goal."
It will be Virani's second spell at the club, having previously led their digital, marketing and commercial operations between 2015 and 2020.
He will also be leaving his role as a board member at non-league club Hashtag United, having accepted the role after spending two years as Rangers' chief commercial officer.
In a club statement, Virani said: "I am proud and honoured to be returning to West Ham United, a club I have a deep affinity and admiration for.
"This is a massive football club with incredibly loyal and passionate supporters, a hugely talented and dedicated group of players and coaches, a proud and unique heritage and an ambition to be as successful as possible.
"I am determined to do everything I can to help the club achieve our objectives, with the absolute priority and focus of everyone here right now on supporting Nuno Espirito Santo and his players as they look to finish the season positively.
"We have a mission to achieve between now and the end of the season - and nothing will distract us from that.
"This club is built on working-class values of hard work, honesty, commitment and togetherness. Those values must continue to be the bedrock of everything we do in the coming weeks and beyond."
Desperation will affect relegation battlepublished at 08:37 BST 29 April
08:37 BST 29 April
Pat Nevin Former footballer and presenter
Image source, Getty Images
There is a huge amount to be said for how desperation can affect teams in a positive way.
Spurs, Nottingham Forest and West Ham each won in the Premier League this weekend. You will search long and hard to find a weekend when that happened this season as they have all struggled to fight clear of relegation.
It is the main reason why predictions are almost impossible at this time of the season. Teams and players cannot be at 100% for every game, but when desperation kicks in, you will get every ounce of effort, even if you can lose some calmness and composure as a result.
Forest and West Ham have been in this mindset for a while now, but it is only now that Spurs have finally woken up and smelled the very bitter coffee.
It was however one of the best 10-minute spells in the league this season when Spurs scored in the 82nd minute to grab two extra points against Wolves. Back in London, West Ham conceded a goal to Everton in the 88th minute, seemingly dropping two of the three points they were holding.
A four-point swing in six minutes was huge at the bottom of the table. But just a few minutes later, West Ham struck through Callum Wilson to grab those two points back again.
In these days of updates live on your phone and all modern technology it was radio gold on BBC 5 Live.
I have listened back to Ian Dennis as he reported on it all happening live and it reminded me why football, even without pictures, can be the best entertainment imaginable. The good news is it is all very likely to happen again and again before the season ends.
West Ham can win 'battle of mentality' with Tottenhampublished at 12:48 BST 28 April
12:48 BST 28 April
Holly Turbutt Fan contributor
Media caption,
West Ham have what it takes to stay up and it is all a battle of mentality between us and Spurs. I'm not saying it's going to be easy, but I'm fully backing the fact that we can do this.
We've got four games remaining, we are two points clear of the drop zone and we just need to focus on getting every point possible.
Our game against Everton showed how much it really means to us all. In the 88th minute, everything seemed lost. We were drawing 1-1, but we showed we have the ability to find a goal from somewhere and the mindset to never call it quits - and that's what I think could keep us in the Premier League.
But the question is: who can take their most recent win and use that for momentum? Because we know Spurs' win over Wolves is something they haven't had in a while and it could give them a little bit of a boost. But West Ham also got a win, we are in better form and it is time to put this to bed.
There was a point when it seemed almost certain West Ham could not reach the 40-point mark and now that is a possibility, with us being four points from what you would typically see as 'safety'.
So one win for us and a loss for Spurs would leave a lot of catching up for them to do, and put us in a far more pleasant situation. So a win away at Brentford would go a very long way to settling some nerves.
We know from our second half of the season that we are one of the more in-form teams, which is ironic given the start of the campaign. But the question remains: can we pull off one enormous comeback to stay in the Premier League?
But, given the atmosphere at the Everton game and the belief these players have, I'm committing to saying West Ham can do it and stay up. Come on, you Irons!
As it stands, Tottenham sit within the relegation zone, two points from safety with West Ham in their sights.
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On the Monday Night Club, former Premier League striker Chris Sutton said: "You look at Spurs and think, well, you have beaten Wolves. They are the team in serious trouble. What they have in their favour is that their goal difference is better than West Ham's."
The Hammers have gained seven points in their last three league games, in comparison to Spurs' four.
"Since the turn of the year, they seem to have a bit of backbone and a bit of spine and a threat going forward. Tottenham messed up with the Igor Tudor appointment – that was the killer for them," added Sutton.
Former Lionesses captain, Steph Houghton said Nuno Espirito Santo's side have more "confidence" in comparison of Roberto de Zerbi's team.
"West Ham have a bit more personality and a bit more fight," she said.
"Jarrod Bowen, the skipper, has got that bit of quality and with Tottenham's injuries, they are going to miss that quality."
Gary: What a tense game for the West Ham fans! At times we we brilliant in defence and attack but still give the ball away far too much. Keep fighting!
Bubba: Catenaccio just does not work in the modern Premier League. We should not have gone into defensive mode at 80 minutes. That tactical shift almost undid a fantastic effort from the team. On the other hand, we won and, if I am such a good manager, why am I not standing on the touchline? So good on you, Nuno!
Tricky Tev: Still looked like we struggle to hold on to a lead. We need Nuno to be more decisive in his substitutions and for us not to play too deep. Some standout individual performances again, however. Soucek looked fresher and added an extra dimension. Mavrapanos (who I have long been critical of) and Disasi have been solid for the past six games or so. Let's hope that Brentford are 'on the beach' for our next game.
John: The players got that result, not Nuno. He was far too negative and their equaliser was always coming. Sat back far too deep. If we survive then it's the players who deserve the credit not this negative Nelly. Come on, you Irons.
Everton fans
Jameson: Incredibly frustrating performance. McNeil should have been dropped after his mistake and poor performance last game, because he had yet another poor game. Barry was hopeless. O'Brien adds nothing. Even when our better players dragged us back into the game the team was not good enough to deserve any points. Another missed opportunity showing our lack of quality and bravery against a nervous and poor West Ham - with the exception of Summerville, who was top class. Oh and VAR - are you joking? Clearly punches the ball out of play and not even an on-field review.
Marko: It seems the squads capable of playing in European competitions are filtering through now. For Everton, there are huge signs of improvement but too much reliance on that talented few. We need more talent - clearly. A miracle needed to qualify now methinks.
Brian: Just coming to terms with the disappointment of last week and then knocked again. There's just not enough steel, skill and strength to Everton's squad to expect a European place. Better than fighting relegation, but that's about it.
Mark: I need someone to explain why reaching around a player to slap the ball out of play is deemed not to be a penalty. VAR is broken.
West Ham will be thinking 'that was our moment'published at 13:22 BST 26 April
13:22 BST 26 April
Chris Wise Final Score reporter
Image source, Getty Images
If West Ham stay up this season, they'll likely point to Saturday's match-winning goal from Callum Wilson and say 'that was our moment.'
I was in the stadium, and the noise when the ball went in was really quite something. Most clubs in West Ham's current predicament probably don't find a way to win that game. Not just because of their league position, but having conceded an equaliser so late on as well. For those with less spirit, there would have been no coming back from that. But clearly, we're talking about a different West Ham team now.
Jarrod Bowen produced another two assists in what is yet another highly productive season. It doesn't seem to matter where the Hammers are in the table, his goal contributions are consistently magnificent.
I really enjoyed his assist for Wilson's winner. Perhaps it was because it wasn't your typical Bowen assist, but his tenacity and bravery to reach the ball was quite something, and then to have the awareness of Wilson's position and the guile to find him with his header was just brilliant.
The outcome of the relegation battle is so tough to call. But West Ham offered another gutsy display which will only cement the internal belief that it isn't going to be them heading to the Championship.
West Ham get 'lucky' with penalty decision - Keownpublished at 12:04 BST 26 April
12:04 BST 26 April
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Match of the Day pundits Steph Houghton and Martin Keown believe West Ham's Matheus Fernandes was "lucky" to escape giving away a penalty in the Hammers' 2-1 win over Everton.
Watch Premier League highlights and analysispublished at 11:07 BST 26 April
11:07 BST 26 April
Pundits Martin Keown and Steph Houghton join host Mark Chapman to bring you the action and talking points from Friday and Saturday's Premier League fixtures.
West Ham 2-1 Everton: What Nuno and Wilson saidpublished at 18:24 BST 25 April
18:24 BST 25 April
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West Ham manager Nuno Espirito Santo speaking to Match of the Day: "We knew it was going to be tough until the end. It was important we keep believing, fighting 'til the last minute. That is something we have in our character and that is positive for us."
On matchwinner Callum Wilson: "Callum is giving us huge moments. We are delighted. Fantastic, what can I say? We have all of the squad available. It [his selection up front] is a good headache to have."
On the remainder of the relegation battle: "It is going to be until the end - keep fighting, keep believing. Tough one but we are in our path."
West Ham goalscorer Callum Wilson speaking to BBC Sport: "Over the moon with the three points first and foremost, and I managed to pop up with the winning goal.
"The atmosphere was electric. I think the fans and the players have really come together in this period and it has stood us in good stead."
On the relegation battle: "We're the ones in the driving seat at the moment and if we take care of our own results, it should stand us in good stead come the end of the season.
"When the goal went in it was a feeling of frustration, but when the eight minutes of added time went up I wanted to go and get that winning goal.
"The lads are buzzing. You do ultimately look at other results, we knew they [Tottenham] were playing a game in which they were the favourites, so we had to do our job."
Did you know?
West Ham United remain unbeaten in each of their last six Premier League home games (won three, drawn three), their best run at the London Stadium since another six-game spell between November 2023 and February 2024.
West Ham United's Callum Wilson has scored nine goals in his last eight Premier League appearances against Everton, and since the 2019-20 campaign, he has scored the most top-flight goals against the Toffees (nine).
Only Bruno Fernandes (11) has recorded more Premier League assists in 2026 than West Ham United's Jarrod Bowen (nine), who now has 10 assists for Tomás Soucek, the first Hammer to assist a teammate 10 times in the competition.